Homemade Chicken Pot Pie Casserole: The Ultimate Comfort Food

There’s something magical about a bubbling, creamy chicken casserole topped with golden biscuits straight out of the oven. Growing up, this was the dish that made a cold night feel like a warm hug. My mom would use leftover rotisserie chicken and whatever veggies we had, and the smell alone was enough to bring everyone to the table. This Homemade Chicken Pot Pie Casserole is a nod to that classic—but simplified and amped up with rich flavor, a silky roux, and flaky biscuit topping.

Let’s dig in.

Key Ingredients for Chicken Pot Pie Casserole & Easy Substitutions

This creamy chicken casserole is flexible and forgiving—just how we like our comfort food casseroles.

Best Chicken for Classic Chicken Pot Pie

• Rotisserie chicken is perfect—juicy and full of flavor.
• Sub: Poached, baked, or leftover southern chicken pot pie style roasted chicken.

Frozen Vegetables for a Chicken and Vegetable Bake

• Classic: Frozen peas and carrots.
• Optional: Frozen corn, green beans, diced potatoes, spinach, or sautéed fresh veggies for a custom chicken and vegetable bake.

Butter Options for Homemade Chicken Casserole

• Use unsalted for control.
• Sub: Olive oil or vegan butter if going dairy-free.

Biscuit Topping for Chicken and Biscuit Casserole

• Shortcut: Refrigerated canned biscuit dough.
• Sub: Homemade biscuits, whole wheat, or puff pastry for a twist on chicken pot pie with biscuits.

How to Make a Creamy Roux for Chicken Pot Pie Bake Without Clumps

This is key. A smooth, lump-free roux sets the base for your classic chicken pot pie flavor.

1. Medium heat only – keeps the flour from burning.
2. Melt butter, then stir in flour and your seasonings.
3. Cook 1–2 minutes, stirring constantly.
4. Slowly whisk in broth and milk.
5. Keep stirring until thick and creamy (3–5 minutes).

(Pro tip: This is where most people mess up—add the liquids gradually, or you’ll end up with paste instead of sauce.)

Full Recipe: Easy Homemade Chicken Pot Pie Casserole

This is a true one-pan chicken casserole wonder—creamy, hearty, and packed with flavor.

Ingredients for a Family-Style Chicken Dinner

• 3 cups cooked chicken, diced or shredded
• 1 cup frozen peas and carrots mix
• 1/2 cup frozen corn (optional)
• 1/3 cup butter
• 1/3 cup all-purpose flour
• 1/2 tsp salt
• 1/4 tsp black pepper
• 1/4 tsp garlic powder
• 1/4 tsp onion powder
• 1 3/4 cups chicken broth
• 2/3 cup milk
• 1 can (16 oz) refrigerated biscuit dough

Step-by-Step Instructions for Chicken Pot Pie Recipe from Scratch

1. Preheat oven to 375°F (190°C).
2. Make the roux: Melt butter in a large skillet. Add flour, salt, pepper, garlic, and onion powder. Cook 1–2 minutes.
3. Add liquids: Slowly whisk in chicken broth and milk. Stir constantly until thickened (about 3–5 minutes).
4. Mix in chicken and vegetables: Add diced chicken, peas, carrots, and corn. Stir to coat.
5. Transfer to baking dish: Spread mixture into a greased 9×13-inch dish.
6. Top with biscuits: Slightly flatten each biscuit and space them evenly on top.
7. Bake for 25–30 minutes until biscuits are golden brown and filling is bubbly.
8. Rest 5 minutes before serving—this is key. The filling sets, and you don’t burn your tongue.

FAQ: Homemade Chicken Pot Pie Casserole

Conclusion: A Classic Chicken Pot Pie You’ll Crave Again and Again

Whether you’re craving a chicken and biscuit casserole, looking for an easy chicken casserole fix, or just want a cozy family-style chicken dinner, this recipe delivers. It’s hearty, flexible, and packed with chicken pot pie goodness in every bite.

Want more comfort food classics?
Follow me on Pinterest for more casseroles, roasts, and home-cooked favorites:
👉 https://www.pinterest.com/emiliorecipes/

More and Related Homemade Chicken Pot Pie Casserole Recipes

• Perfect Chicken Pot Pie
• Chicken Pot Pie with Biscuits
• Easy Cheesy Chicken Parmesan Bake
• Creamy Smothered Chicken and Rice
• Street Corn Chicken Rice Bowl

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